Head and neck cancer: metronomic chemotherapy
نویسندگان
چکیده
منابع مشابه
Neoplastic chemotherapy and head and neck cancer.
Sulphur mustard was synthesized in 1854 and its vesicant properties described in 1887. Medical attention was focused on the chemical during World War I when its vesicant action on the skin, eyes and respiratory tract was noted in full and it was developed as a chemical weapon. It became apparent that those who survived gassing with sulphur mustard frequently developed leukopenia and in those th...
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Numerous studies have shown cisplatin-based chemotherapy to be effective in the treatment of head and neck cancer. Cisplatin/5-fluorouracil (5-FU) is the most frequently used combination regimen, but neurotoxicity, ototoxicity, and renal toxicity limit repeated dosing (for long-term treatment of responding patients) and dose intensification. In studies to date, the analogue carboplatin appears ...
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The role of chemotherapy in the management of patients with head and neck cancer continues to evolve. Single-agent methotrexate or cisplatin, or the combination of cisplatin and infusional fluorouracil can be considered standard therapy for patients with recurrent disease. Neoadjuvant chemotherapy is being actively pursued. Although enhanced survival has not yet been demonstrated, the goal of o...
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Head and neck cancer is best managed in a multidisciplinary setting. Surgery, radiation therapy, chemotherapy and, more recently, biologic therapy are often employed in various combinations in an attempt to eradicate both clinically apparent and occult disease. The goals of treatment include maximizing tumor control while maintaining function and quality of life. Most patients present with loca...
متن کاملOutcomes of Induction Chemotherapy for Head and Neck Cancer Patients
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked and analyzed. We enrolled patients wh...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2015
ISSN: 1471-2407
DOI: 10.1186/s12885-015-1705-z